Causal effects of lung function on brain cortical and subcortical structure: a two-sample univariable and multivariable Mendelian Randomization study

Key Points

• Lung function significantly affects brain structure, particularly in cortical and subcortical areas.
• A causal relationship was identified using two-sample Mendelian randomization techniques, enhancing understanding of brain health.
• Analysis employed both univariable and multivariable Mendelian randomization to establish these connections.
• Outcomes suggest that optimizing lung function may have cognitive benefits, indicating the need for further research into lung-brain interactions.