Neonatal brain masculinization via estrogen receptor affects sex differences in hippocampal learning and plasticity during early development

Key Points

• Hippocampal learning and plasticity differ based on estrogen receptor activity, indicating hormonal influence during development.
• Sex differences in brain structure highlight the importance of estrogen receptor engagement in early neonatal neurodevelopment.
• Observational analysis involved assessing estrogen receptor effects on neurotransmitter pathways in developing brains.
• Findings suggest that variations in brain masculinization may affect cognitive development, emphasizing the need for future studies.