Population pharmacokinetic model-based IVIVC incorporating active metabolite kinetics: Application to aceclofenac sustained-release formulations

Key Points

• Active metabolite kinetics significantly influence the pharmacokinetic profile of aceclofenac formulations, enhancing therapeutic efficacy.
• The model predicts variable absorption rates, revealing discrepancies in bioavailability between immediate and sustained-release formulas.
• Population pharmacokinetic modeling provides insight into individual variability in drug metabolism, supporting personalized medicine approaches.
• The study suggests that understanding active metabolite behavior may lead to improved formulation design and patient outcomes.