UDP-GlC:glycoprotein glucosyltransferase-glucosidase II, the ying-yang of the ER quality control

Key Points

• The interaction of glucosyltransferase and glucosidase is crucial for glycoprotein processing.
• Key metrics of ER quality control are influenced by these enzymes' balance, affecting protein fate.
• Analysis of molecular pathways shows how glucosidase II contributes to glycoprotein maturation in ER.
• Understanding these mechanisms may enable advances in therapeutic strategies for protein misfolding disorders.