Serine Proteinase Inhibitor (Serpin) E1 As an Early Urine Biomarker of Subclinical Renal Fibrosis in Children with Transplant Associated Thrombotic Microangiopathy (TA-TMA)

Key Points

• Serpin E1 levels significantly correlate with renal fibrosis in affected children, indicating potential for early diagnosis.
• The study found elevated serpin E1 in urine, linking it with subclinical renal changes.
• Assessment using urine biomarker levels reveals insights into the progression of TA-TMA-related complications.
• Identifying serpin E1 could lead to timely interventions in children with transplant-associated conditions.