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Molecular devolution in chronic myelomonocytic leukemia during treatment with decitabine/cedazuridine: A case report | Synapse
March 3, 2026
Open Access
Molecular devolution in chronic myelomonocytic leukemia during treatment with decitabine/cedazuridine: A case report
KG
Klaus Geissler
Sigmund Freud Privatuniversität Wien
GM
Gerlinde Mitterbauer-Hohendanner
RJ
Roland Jäger
Medical University of Vienna
Key Points
Molecular devolution was observed in a chronic myelomonocytic leukemia case during therapy.
Significant changes in biomarkers were noted after the decitabine treatment.
Observational analysis documented the effects of decitabine and cedazuridine on leukemia progression.
The findings underscore the need for ongoing monitoring to assess treatment impacts in chronic myelomonocytic leukemia.
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Geissler et al. (Wed,) studied this question.
synapsesocial.com/papers/69a76030c6e9836116a2cac5
https://doi.org/https://doi.org/10.1007/s00277-026-06850-3