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Cytopenias and Infectious Complications Following CD19-Directed CAR-T cell Therapy in Patients with B-ALL | Synapse
March 3, 2026
Cytopenias and Infectious Complications Following CD19-Directed CAR-T cell Therapy in Patients with B-ALL
KG
Kriti Gera
University of South Florida
FA
Fnu Amisha
FI
Filip Ionescu
Moffitt Cancer Center
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Key Points
Cytopenias commonly occur, leading to increased risk of severe infections.
Overall, 30% of patients developed significant infections during treatment.
Analysis of clinical outcomes focused on patients with B-ALL receiving CAR-T therapy.
These findings underscore the importance of monitoring patients for infections post-therapy.
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Gera et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76063c6e9836116a2d141
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.169