Cafestol-derivatives as potential FXR agonists and CYP7A1 inhibitors and their impact on hypercholesterolemia: an in silico study

Key Points

• Cafestol-derivatives show promise as FXR agonists, significantly influencing cholesterol metabolism.
• In silico analysis revealed these compounds could inhibit CYP7A1, involved in bile acid synthesis.
• Predictive modeling indicated potential reductions in hypercholesterolemia with these interventions.
• These findings support further exploration of cafestol-derivatives for therapeutic application.,