Interpretable ADC-based radiomics models for differentiating hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Key Points

• The ADC-based model robustly differentiates hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC), showcasing its effectiveness.
• Validated with public data, the model demonstrates strong generalizability across heterogeneous cases to be clinically useful.
• Assessment using ADC-based radiomics reveals high accuracy in differentiation with significant implications for patient diagnosis.
• These findings suggest that adopting this non-invasive tool may enhance diagnostic clarity in liver cancer types like HCC and ICC.