HMGA2 promotes hepatocellular carcinoma progression by regulating tumor-associated macrophage via Notch1/CCL2 signaling

Key Points

• Hepatocellular carcinoma progression is promoted by HMGA2 through its regulation of immune cells.
• Evidence shows that CCL2 signaling through Notch1 is critical for the activity of HMGA2.
• The method utilized involved analyzing the interaction between HMGA2 and macrophage signaling pathways.
• Findings suggest targeting HMGA2 may offer new therapeutic strategies for hepatocellular carcinoma treatment.