Positive predictive value of the prostate imaging reporting and data system combined with single related indicators in prostate cancer across different prostate zones | Synapse
March 3, 2026Open Access
Positive predictive value of the prostate imaging reporting and data system combined with single related indicators in prostate cancer across different prostate zones
Key Points
The enhanced positive predictive value relates directly to specific clinical indicators for diagnosis.
Increased PPV was noted when the PSA levels reached >10 ng/mL or PSAd was ≥0.15 ng/mL.
Observational analysis across different prostate zones with clinical indicators improves accuracy of detection.
The findings suggest potential improvements in prostate cancer screening by integrating additional indicators.
Abstract
Combining the PI-RADS with other clinical indicators effectively enhanced its initially low PPV for transitional zone lesions, particularly when the PSAd was ≥0.15 ng/mL2 or the PSA was >10 ng/mL.