Pre-Transplant Inflammation Promotes Endothelial to Mesenchymal Transition in Pediatric TA-TMA

Key Points

• Endothelial to mesenchymal transition occurs significantly due to increased inflammation in TA-TMA cases.
• Key evidence shows that inflammation levels correlate with the degree of endothelial to mesenchymal transition observed.
• Assessment using cellular pathways elucidates the inflammatory effects in pediatric patients with TA-TMA.
• Findings suggest potential therapeutic targets for addressing inflammation and its impact on TA-TMA.