P2X4 receptors on myeloid cells mediate tissue injury in a model of trauma and hemorrhagic shock in male mice

Key Points

• Tissue injury is significantly mediated by P2X4 receptors on myeloid cells during trauma.
• The study finds a notable increase in injury markers post-hemorrhagic shock in male mice.
• Analysis involved a model of trauma and hemorrhagic shock to assess receptor involvement.
• These findings highlight a potential new target for therapeutic intervention in traumatic injuries.