A randomized controlled trial of cryoprobe versus forceps for transbronchial biopsy (FROSTBITE-2): Study protocol for a multi-center pragmatic clinical trial | Synapse
March 3, 2026
A randomized controlled trial of cryoprobe versus forceps for transbronchial biopsy (FROSTBITE-2): Study protocol for a multi-center pragmatic clinical trial
Key Points
Cryoprobe may offer advantages over forceps for transbronchial biopsy procedures, and shows promise in improving patient outcomes.
The trial examines 300 patients in multiple centers to assess the effectiveness of two biopsy techniques.
Randomized controlled trial protocol designed to facilitate comparisons of biopsy effectiveness across different clinical sites.
Results can inform clinical practices, enhancing the quality of transbronchial biopsy techniques while outcomes are yet to be determined.