Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses

Key Points

• Memory vulnerabilities to acute stresses are influenced by estrogen levels in the hippocampus, particularly differing by sex.
• Key differences were observed in receptor types that modulate memory processes under stress conditions.
• The analysis highlighted the role of epigenetics in shaping these vulnerabilities, suggesting complex regulatory mechanisms.
• These findings underline the importance of considering sex differences in stress-related memory issues, advocating for tailored interventions.