Modulation of AMPK/SIRT1 signaling by piribedil attenuates cyclophosphamide-induced nephrotoxicity via PI3K/Akt, MAPKs, and TLR4/NLRP3 pathways with regulation of KIM-1/NGAL

Key Points

• Piribedil significantly reduces cyclophosphamide-induced nephrotoxicity by modulating ampk/sirt1 signaling.
• The study shows a marked decrease in renal injury biomarkers, including kim-1 and ngal, with treatment.
• Analysis reveals modulation of cellular pathways, specifically pi3k/akt and mapks, contributing to nephroprotection.
• The findings highlight potential therapeutic avenues against nephrotoxicity, needing further clinical validation.