Rational molecular design and emerging applications of small-molecule sonosensitizers for sonodynamic therapy

Key Points

• Sonodynamic therapy shows increased efficacy with novel sonosensitizers designed to target specific tumor environments.
• A key finding indicates that these small molecules significantly enhance therapeutic outcomes in preclinical models.
• Analysis of molecular design focuses on optimizing sonosensitizers for better tumor penetration and selectivity.
• Highlighting the need for further studies, these findings show potential but require validation in clinical settings.