Normal tissue complication probability models for gastrointestinal toxicity after adjuvant (chemo)radiotherapy for cervical cancer in the PARCER trial

Key Points

• Persistent gastrointestinal toxicity increases with higher bowel V30Gy and V40Gy exposures, indicating dose sensitivity.
• Acute and late diarrhea risks are associated with postoperative radiotherapy and 3DCRT modalities.
• Assessment of NTCP models reveals a need for bowel delineation consensus and consideration of additional variables.
• This study highlights the need for external validation and broader application of toxicity models for improving outcomes.