March 3, 2026Diabetes Research and Clinical Practice0 citationsOpen Access

Low maternal folic acid during pregnancy exacerbates ectopic fat accumulation in the liver and muscle of male offspring

TKTomoyo Kawakubo‐YasukochiKyushu University YHYoshikazu HayashiFukuoka Dental College KTKaren TanAgency for Science, Technology and Research

Key Points

Ectopic fat accumulation is linked to maternal folic acid status in male offspring, indicating a crucial nutrient role.
Adequate maternal plasma folic acid levels are vital for preventing metabolic health issues, especially in males.
The analysis emphasizes the importance of maternal nutrition over mere dietary intake for offspring health.
Findings highlight the need for awareness on maternal folic acid to improve male offspring metabolic outcomes.

Abstract

Maternal FA status plays a critical role in regulating male offspring metabolic health. Maintaining adequate maternal plasma FA levels, rather than focusing solely on dietary intake, may be essential for preventing ectopic fat accumulation in the next generation.

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