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S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway | Synapse
March 3, 2026
S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway
YW
Yajun Wang
WC
Wenjie Chen
Commercial Aircraft Corporation of China (China)
WL
Wei Liu
Fujian Medical University
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Key Points
Malignant progression is significantly promoted by S100A10 through glycolysis.
Activation of the HK2/ERK signaling pathway is critical in this process.
This analysis highlights the relationship between S100A10 and cancer metabolism.
Findings could indicate a new approach to treating CCA by targeting S100A10.
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Wang et al. (Tue,) studied this question.
synapsesocial.com/papers/69a7619fc6e9836116a2fa8d
https://doi.org/https://doi.org/10.1007/s12094-026-04237-4