Synergistic antidepressant effects of Salvianolic acid B and Paeonol in CUMS-treated rats

Key Points

• Combined treatment of salvianolic acid B and paeonol significantly improves antidepressant effects in response to chronic stress.
• The study shows a notable increase in serotonin levels after treatment with these compounds in animal models.
• Assessment used the cumulative stress model to simulate depression-like symptoms in rats treated with both compounds.
• The findings suggest promising developments for combination therapies in treating depression, needing further validation in clinical settings.