Lack of genetic evidence for a role of SLC25A46 in alpha-synucleinopathies
Key Points
Alpha-synucleinopathies show no genetic link to slc25a46 variants, indicating minimal influence on disease risk.
The analysis involved genetic evidence from patients with Parkinson's disease (PD), REM sleep behavior disorder (RBD), and dementia with Lewy bodies (DLB).
Analysis of genetic variants found no association of slc25a46 with the aforementioned conditions, using comprehensive data assessment.
The lack of association implies that slc25a46 may not be a viable target for further genetic studies or therapeutic approaches.
Abstract
SLC25A46 variants showed no evidence of association, suggesting the gene does not play a major role in PD, RBD, or DLB risk.
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Lack of genetic evidence for a role of SLC25A46 in alpha-synucleinopathies | Synapse