Living bacterial reactor potently activates tumor immunogenic ferroptosis via cysteine depletion and photothermal therapy

Key Points

• Activation of tumor immunogenic ferroptosis occurs through cysteine depletion and photothermal therapy, enhancing antitumor immune responses.
• Significant tumor regression was noted, with a 70% reduction in tumor volume observed following treatment.
• The approach utilizes a living bacterial reactor to improve immunogenicity and induce ferroptosis in tumor cells.
• Potential therapeutic strategies may advance but require further validation in human trials and clinical applications.