March 3, 2026Open Access

Age-Dependent Effects of Losartan and Exercise on Skeletal Muscle Redox Balance and Protein Turnover in Mice

Key Points

Altered redox balance and protein turnover are linked to age-dependent responses to interventions.
In aged mice, exercise impacts skeletal muscle differently than losartan based on oxidative status.
Assessment using losartan and exercise in mice reveals age-related variations in muscle health.
These findings support considering age in designing treatments for age-related muscle loss.

Abstract

While exercise is a robust intervention, losartan's efficacy is critically dependent on the animal's baseline oxidative status. These findings highlight the importance of considering age as a critical factor when designing pharmacological interventions for age-related muscle atrophy.

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Cite This Study

Lin et al. (Sun,) studied this question.

synapsesocial.com/papers/69a76611badf0bb9e87db85e https://doi.org/https://doi.org/10.1016/j.bj.2026.100951

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