A recent study found that applying gamma-frequency (40 Hz) transcranial alternating current stimulation (γ-tACS) over the precuneus in Alzheimer’s disease (AD) patients temporarily improved the patients’ episodic memory and function of the cholinergic system.1 γ-tACS incites physiological gamma oscillations in cortical neurons with disturbed or decreased high-frequency oscillatory activity.2 First noted by Assogna et al.3, the cellular death of cortical GABAergic interneurons has been observed in a TARDBP-overexpressing mouse model of frontotemporal dementia (FTD) which might result in a decrease in gamma-frequency oscillations due to the loss of inhibitory control by interneurons.
Etelämäki et al. (Mon,) studied this question.