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Cisplatin disrupts OCT1-DNMT1-piRNA epigenetic regulatory axis to suppress GAB2-mediated aggressiveness in OSCC | Synapse
March 3, 2026
Cisplatin disrupts OCT1-DNMT1-piRNA epigenetic regulatory axis to suppress GAB2-mediated aggressiveness in OSCC
AL
Anthony Lalruatfela
National Institute of Technology Rourkela
PB
Priyajit Biswal
National Institute of Technology Rourkela
SB
Subham Kumar Behera
National Institute of Technology Rourkela
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Key Points
Cisplatin treatment significantly reduced GAB2 expression, impacting tumor aggressiveness in oral squamous cell carcinoma.
Reduction in aggressiveness was linked to the disruption of the OCT1-DNMT1-piRNA epigenetic regulatory axis.
Analysis focused on oral squamous cell carcinoma (OSCC) cells to understand treatment effects on aggressiveness.
Research highlights the potential of targeting epigenetic pathways for therapeutic strategies against OSCC.
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Lalruatfela et al. (Tue,) studied this question.
synapsesocial.com/papers/69a7669bbadf0bb9e87ddac8
https://doi.org/https://doi.org/10.1016/j.abb.2026.110756
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