Does aspirin resistance correlate with clinical stroke severity in acute ischemic stroke patients?
Aspirin resistance is prevalent among acute ischemic stroke patients but does not appear to correlate with initial clinical severity.
Objective: Ischemic stroke outcomes are influenced by initial severity. We aimed to explore the relationship between aspirin resistance (AR) and stroke severity. Introduction: Stroke severity significantly affects clinical outcomes. Established tools like NIHSS and MRS assess severity, yet the link between aspirin resistance and these measures remains uncertain. Material and Methods: We enrolled 100 acute ischemic stroke patients, assessing severity with NIHSS and MRS and aspirin resistance using the Innovance PFA 200 system. Statistical analyses employed SPSS 20.0. Results: Of 100 patients (mean age 61 years, 55% male), 32% showed aspirin resistance. While NIHSS and MRS correlated with certain clinical parameters, no significant correlation was found between aspirin resistance and stroke severity. Discussion: Despite expectations, no significant link emerged between aspirin resistance and stroke severity measured by NIHSS/MRS. Other factors may outweigh aspirin responsiveness in influencing stroke severity. The positive correlation between age and aspirin resistance merits further exploration for treatment implications in older stroke patients. Conclusion: Aspirin resistance was prevalent among acute stroke patients but didn’t impact stroke severity as measured by NIHSS and MRS. This underscores the need for personalized stroke management approaches. Keywords: Aspirin resistance, Stroke, NIHSS Scale, MRS scale,
Lichkova et al. (Mon,) studied this question.