Bridging the translational gap in HNSCC immunotherapy: From resistance mechanisms to high-fidelity preclinical models

Key Points

• Evidence highlights critical resistance mechanisms in head and neck squamous cell carcinoma, impacting treatment success.
• High-fidelity preclinical models directly address these resistance mechanisms in a realistic environment.
• Insights from this analysis provide a framework for improving immunotherapy approaches in HNSCC.
• Further developments in targeted therapies may enable overcoming these resistant profiles.