Photocatalytic Synthesis of (Hetero)biaryls via Palladium-Catalyzed Hybrid-Radical Cross-Coupling of (Hetero)aryl Halides and C–H Functionalization of Heteroarenes

Key Points

• This method enables the radical C-H arylation of heterocycles without an external photocatalyst, enhancing sustainability.
• The broad functional-group tolerance (up to 95%) allows for diverse applications in complex bi-(hetero)-aryl synthesis.
• Analysis features the palladium catalyst reaction under mild conditions, making it accessible and efficient for various substrates.
• These findings highlight new possibilities in photoactivated palladium catalysis, with implications for future C-C bond formation strategies.