Clinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis

Key Points

• Complete response rates are higher with more intensive total neoadjuvant therapy protocols, indicating treatment effectiveness.
• A key finding shows that smoking cessation may improve treatment outcomes, highlighting a lifestyle factor in patient recovery.
• Observational analysis across multiple centers evaluated clinical and treatment-related predictors of complete response in rectal cancer patients.
• Increasing smoking cessation efforts may support treatment success; further validation is needed before implementing changes.