Ginsenoside Rg5 targets the KAT8-CISD2 axis to maintain mitochondrial homeostasis and antagonize senescence

Key Points

• Maintaining mitochondrial homeostasis is crucial for counteracting cellular senescence, highlighting its importance in aging.
• KAT8-mediated acetylation of CISD2 at K74 directly inhibits ubiquitin-mediated degradation, preserving mitochondrial function and integrity.
• Using ginsenoside Rg5 activates the KAT8-CISD2 axis, indicating that this natural compound may have significant anti-aging effects.
• The findings support further investigation into KAT8 as a promising target for developing anti-aging interventions, potentially transforming treatments for age-related conditions.