Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury

Key Points

Myocardial ischemia-reperfusion injury is significantly attenuated by the natural products, improving mitochondrial function.
Specific activation of the SIRT1/3-PGC-1α-NRF2 pathway indicates a potential therapeutic target for cardiac protection.
Analysis demonstrates modulation of PINK1/Parkin-dependent mitophagy, vital for restoring mitochondrial homeostasis.
Utilizing these natural products presents a novel approach, yet further studies are needed for clinical validation.

Abstract

PRC attenuates MIRI by activating the SIRT1/3-PGC-1α-NRF2 pathway to modulate PINK1/Parkin-dependent mitophagy, thereby restoring mitochondrial homeostasis. Our study elucidates a novel mechanism underlying this natural product combination and highlights the SIRT1/3 axis as a promising therapeutic target for cardioprotection.

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Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury

Key Points

Abstract

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