Toward Microbiome-Informed Melanoma Care: The Gut Microbiota in Melanoma Evolution, Immunotherapy Response and Immune-Related Toxicity

Key Points

• Melanoma progression correlates with variations in gut microbiota, suggesting a critical role in disease evolution.
• Response rates to immunotherapy in melanoma patients improve with beneficial microbiota presence, highlighting treatment implications.
• Analysis of microbiota interactions reveals links to immune-related toxicity during treatment, signaling caution in clinical settings.
• Understanding these relationships may enable personalized approaches in melanoma management and improve patient outcomes.