Oncostatin M upregulates CD73 via the MAPK pathway in keratinocytes to promote an adenosine-dependent anti-inflammatory response in psoriasis

Key Points

• Increased CD73 expression enhances the adenosine-mediated anti-inflammatory response in keratinocytes.
• A significant association between Oncostatin M and the activation of the MAPK pathway was observed.
• Keratinocytes were used to study the interaction of Oncostatin M and CD73 in a psoriatic context.
• Findings highlight the potential for new therapeutic strategies targeting the CD73/adenosine axis in psoriasis.