March 3, 2026Open Access

Citrate silver nanoparticles modulate estrogen signaling in estradiol-supplemented ER-positive breast cancer cells

Key Points

Modulating estrogen signaling presents a promising direction for breast cancer therapy, particularly with ER-positive cells.
Significant findings show how silver nanoparticles interact with estrogen receptors, influencing cellular functions.
Assessment using silver nanoparticles examines their cytotoxicity and potential benefits in conjunction with estradiol.
Highlights the need for more endocrine research on nanoplastics pollution's role in breast cancer treatment strategies.

Abstract

Our results suggest that the surface chemistry of silver nanoparticles may facilitate their ability to modulate estrogen signaling and interact with the estrogen receptor. Furthermore, the nanoplastics pollution may influence the cytotoxicity of silver nanoparticles. This paper highlights the importance of endocrine research in breast cancer, particularly within the context of nanoplastics pollution and the use of nanotechnology in breast cancer treatment.

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Cite This Study

Rakowski et al. (Thu,) studied this question.

synapsesocial.com/papers/69a767c5badf0bb9e87e246c https://doi.org/https://doi.org/10.1016/j.mce.2026.112741

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