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Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma | Synapse
March 3, 2026
Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma
WM
Weifang Ma
Chinese Academy of Medical Sciences & Peking Union Medical College
XG
Xuelian Gao
Guangdong Provincial Center for Disease Control and Prevention
GZ
Ge Zeng
Nanfang Hospital
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Key Points
Asiatic acid promotes enhanced CD8+ T cell-mediated antitumor immunity.
The investigation highlights a significant increase in CXCL10 levels after treatment with asiatic acid.
Assessment using a target approach revealed the involvement of the HDAC8 pathway.
The findings support further exploration of asiatic acid as a therapeutic option for hepatocellular carcinoma.
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Liu et al. (Thu,) studied this question.
synapsesocial.com/papers/69a767ebbadf0bb9e87e2e34
https://doi.org/https://doi.org/10.1038/s41401-025-01739-9