MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy

Key Points

• Cardiac dysfunction is significantly attenuated in the presence of MOTS-c after high altitude exposure, indicating a protective role.
• Notably, mitochondrial function improved by 40% in conditions of oxidative stress when treated with MOTS-c.
• Analysis shows that MOTS-c promotes mitophagy, a crucial process for cellular energy maintenance during high altitude stress.
• This highlights the need for further exploration of MOTS-c as a therapeutic strategy for altitude-related cardiac issues.