dMMR killer: A conditional suicide gene that preferentially kills DNA mismatch repair-deficient cells

Key Points

• Conditional suicide gene preferentially induces apoptosis in tumor cells lacking DNA mismatch repair.
• Apoptosis rates reached 80% in DNA mismatch repair-deficient cells, highlighting its potential efficacy.
• Assessment utilized targeted genetic modifications to evaluate effects on cell viability in vitro.
• This approach may lead to tailored therapies for cancer types characterized by mismatch repair deficiencies.