Metabolomic analysis of macrocyclic lactone susceptible and resistant isolates of Dirofilaria immitis

Key Points

• The analysis identifies distinct metabolomic profiles associated with susceptibility and resistance to macrocyclic lactones.
• Key metabolites were significantly different between 10 susceptible and 10 resistant Dirofilaria immitis isolates.
• Metabolomic profiling employed advanced techniques to elucidate biochemical pathways in the parasites.
• Insights may inform targeted therapeutic strategies against resistant Dirofilaria immitis strains.