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March 3, 2026
Open Access
Potentiation of active locomotor state by spinal-projecting serotonergic neurons
SF
Sara J. Fenstermacher
AV
Ann Vonasek
AC
Anne E. Cavanagh
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Key Points
Enhanced locomotor state is achieved through the activation of spinal-projecting serotonergic neurons,
Locomotion increased significantly during activation of these neurons, highlighting a pivotal role in motor control.
Observational analysis using neural pathways illustrated the intricate behaviors driven by these neuronal connections.
Findings suggest a deeper understanding of spinal cord mechanisms, emphasizing potential therapeutic targets for mobility issues.
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Cite This Study
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Fenstermacher et al. (Sun,) studied this question.
synapsesocial.com/papers/69a768a3badf0bb9e87e56c1
https://doi.org/https://doi.org/10.1016/j.neuron.2025.12.008
Potentiation of active locomotor state by spinal-projecting serotonergic neurons | Synapse