Background: Vitamin D plays a significant role in immune regulation. Its deficiency has been associated with increased levels of inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Methods: This retrospective study was conducted at Princess Iman Center, King Hussein Medical City, Jordan, between January and April 2022. Medical records of 600 adult patients were analyzed. Serum 25H) vitamin D, CRP, and ESR were measured. SPSS version 26 was used for statistical analysis. Results: A statistically significant inverse correlation was found between vitamin D levels and both CRP (r = -0.53, p < 0.001) and ESR (r = -0.48, p < 0.001). Patients with vitamin D deficiency (<20 ng/mL) exhibited significantly higher CRP and ESR values. Conclusion: Vitamin D deficiency is associated with elevated levels of inflammatory markers. Monitoring and correcting vitamin D status may be beneficial in controlling chronic inflammation.
Abu-alkeshek et al. (Tue,) studied this question.