CSF Proteomic Profiles Associated With White Matter Integrity in Cognitively Normal Older Adults With and Without Amyloid Pathology

Key Points

• This research aims to explore the connection between CSF proteomic profiles and white matter integrity in older adults, particularly concerning amyloid pathology.
• Analyzed CSF proteomic profiles in older adults with and without amyloid pathology.
• Evaluated white matter integrity using advanced imaging techniques.
• Assessed the relationship between biological markers and cognitive function.
• Identified distinct proteomic profiles associated with white matter integrity.
• Noted correlations between neuronal plasticity alterations and changes in oligodendrocyte integrity.
• Demonstrated that amyloid pathology impacts these biological processes in cognitively normal individuals.

Abstract