Lianqiaobaidu powder alleviates cardiac dysfunction in CVB3-infected mice by targeting viral replication, inflammation, and apoptosis via key constituents Nodakenin, Isosakuranin, and Epicatechin gall
Lianqiaobaidu powder and its active constituents demonstrate complementary mechanisms in alleviating viral myocarditis in preclinical models.
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• Lianqiaobaidu powder alleviates cardiac dysfunction and injury in CVB3-infected mice. • Nodakenin, Isosakuranin, and Epicatechin gallate are key LQBDP anti-VMC constituents. • Nodakenin inhibits CVB3 replication in cardiac fibroblasts via the MEK pathway. • Isosakuranin reduces inflammation in CVB3-infected macrophages via the RAGE pathway. • Epicatechin gallate blocks CVB3-induced cardiomyocyte apoptosis via the TNFR pathway.
Tang et al. (Sun,) reported a other. Lianqiaobaidu powder alleviates cardiac dysfunction in CVB3-infected mice by targeting viral replication, inflammation, and apoptosis via key constituents Nodakenin, Isosakuranin, and Epicatechin gall.