Preoperative stress combined with aseptic noncardiac surgery induced myocardial injury in Wistar rats, shown by elevated hs-cTnI and structural heart changes.
Does preoperative stress combined with noncardiac surgery induce myocardial injury in old Wistar rats?
Preoperative stress combined with noncardiac surgery can induce myocardial injury in healthy Wistar rats, highlighting the potential role of stress in perioperative cardiac complications.
Absolute Event Rate: 0% vs 0%
The work was performed on 4 groups of old Wistar rats: anesthesia only (An), noncardiac surgery (NS), extracardiac surgery (ES) with prior stress for 5 days (SNS), and intact animals used as a control. As evident from the absence of increases in proinflammatory cytokines and C-reactive protein 10 days after the surgery, the animals did not have any inflammation. The presence of stress was judged by the highest level of corticosterone in the SNS rats. These animals had myocardial injury after NS (MINS) indicated by structural and metabolic disorders, as well as an increase in the blood concentration of high-sensitive cardiac troponin I (hs-cTnI). Despite the fact that the rats in the An and NS groups had some ischemic zones in the myocardium, they did not develop MINS, since there was no oxidant-antioxidant imbalance and, most importantly, no increase in hs-cTnI. This study showed for the first time that “simple” aseptic noncardiac surgery in combination with preoperative stress can induce MINS in healthy Wistar rats. It is proposed to use a decrease in the level of superoxide dismutase as an additional biomarker of MINS.
M. V. Kondashevskaya (Wed,) reported a other. Preoperative stress combined with aseptic noncardiac surgery induced myocardial injury in Wistar rats, shown by elevated hs-cTnI and structural heart changes.