What does this research mean for the field?

Local dose optimisations should be conducted for PET-CT and PET-MR examinations despite the availability of local diagnostic reference levels (DRLs) in Nuclear Medicine. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review aims to evaluate the methodology used in PET studies focusing on low activity levels of radiopharmaceuticals.

March 6, 2026Open Access

A narrative review of the methodology deployed in PET studies investigating low activity levels of radiopharmaceuticals

Key Points

This review aims to evaluate the methodology used in PET studies focusing on low activity levels of radiopharmaceuticals.
Narrative review of existing literature on PET studies
Assessment of diagnostic reference levels in Nuclear Medicine
Discussion on dose optimization techniques
Identified importance of local diagnostic reference levels (DRLs) in Nuclear Medicine.
Suggested that local dose optimizations remain necessary despite existing DRLs.
Highlighted variations in methodology across different PET examinations.

Abstract

This narrative review suggests that, whilst local diagnostic reference levels (DRLs) are available in Nuclear Medicine, local dose optimisations should still be conducted for PET-CT and PET-MR examinations.

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