FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis

Key Points

• The study aims to explore how FASN inactivation affects progranulin expression and its role in cell death and leukemogenesis.
• Investigated FASN inactivation in cellular models
• Assessed progranulin expression levels
• Examined lysosome involvement in cell death pathways
• FASN inactivation led to increased progranulin expression
• Enhanced lysosome-dependent cell death was observed
• Suppression of leukemogenesis was noted in treated models