What question did this study set out to answer?

To construct an immune network and evaluate prognostic significance of checkpoint genes in endometrial cancer.

March 6, 2026Open Access

Immune Network Construction and Prognostic Evaluation of Checkpoint Genes in Endometrial Cancer Using STRING, MCODE, and GEPIA2.

Key Points

To construct an immune network and evaluate prognostic significance of checkpoint genes in endometrial cancer.
Used in silico techniques to construct immune networks
Applied STRING for protein-protein interactions
Utilized MCODE for identifying significant modules
Employed GEPIA2 for expression data analysis
Identified checkpoint-centered hubs within the immune network
Highlighted immune programs with prognostic relevance
Supported rationale for biomarker-guided immunotherapy

Abstract

This in silico immune network highlights checkpoint centered hubs and coordinated immune programs with prognostic relevance in endometrial cancer, providing a rationale for biomarker guided immunotherapy development and patient stratification. Validation in independent cohorts and correlation with clinicopathologic and treatment response data are needed to support clinical translation.

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