Milrinone infusion at 0.5 µg·kg⁻¹·min⁻¹ increased cardiac output from 65.0 to 89.5 mL·min⁻¹·kg⁻¹ in a canine acute ischemic heart failure model, a 37.7% improvement.
What are the hemodynamic effects of milrinone in normal and failing canine hearts?
Effect estimate: Percent increase of ~37.7%
Absolute Event Rate: 89.5% vs 65%
p-value: p=<0.05 (statistically significant increase)
Supplementary figures and tables associated with the manuscript submitted to the American Journal of Physiology-Heart and Circulatory Physiology.
Hiraki et al. (Wed,) conducted a other in Canine model of acute ischemic heart failure induced by coronary microembolization (n=5). Milrinone infusion vs. Baseline (no milrinone) was evaluated on Cardiac output (measured as aortic flow per unit body weight, mL·min⁻¹·kg⁻¹) (Percent increase of ~37.7%, p=<0.05 (statistically significant increase)). Milrinone infusion at 0.5 µg·kg⁻¹·min⁻¹ increased cardiac output from 65.0 to 89.5 mL·min⁻¹·kg⁻¹ in a canine acute ischemic heart failure model, a 37.7% improvement.
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