What question did this study set out to answer?

This research aims to explore the relationship between APOE genotype status and imaging features in Alzheimer Disease patients considered for antiamyloid therapy.

March 7, 2026Open Access

Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy

Key Points

This research aims to explore the relationship between APOE genotype status and imaging features in Alzheimer Disease patients considered for antiamyloid therapy.
Evaluated a cohort of Alzheimer Disease patients for lecanemab therapy
Used SWI and GRE sequences to detect microhemorrhages
Assessed associations between APOE genotype and imaging findings
Significant association between APOE genotype and the number of microhemorrhages
Higher mean counts of microbleeds detected on SWI compared to GRE
No significant associations with white matter hyperintensities or cognitive impairment

Abstract

In this cohort of patients with AD being evaluated for lecanemab therapy, a significant association was identified between APOE genotype and the number of microhemorrhages with higher mean counts of microbleeds detected on SWI sequence compared with microbleeds detected on the GRE sequence of the same patients. No significant associations were found between APOE genotype and WMH, PVS, or cognitive impairment.

Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy

Key Points

Abstract

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