Electronic Modification of Hexa-2,4-diyne-1,6-diols: Predictive Access to Strained Cyclobutenes and 3(2H)-Furanones

Key Points

• To enhance the formation yields of strained cyclobutenes and 3(2H)-furanones from hexa-2,4-diyne-1,6-diols.
• Utilized acid-mediated activation of hexa-2,4-diyne-1,6-diols to initiate reactions.
• Assessed the effects of electron modification on reaction efficiency.
• Analyzed product formation and yields using spectroscopic methods.
• Demonstrated improved yields compared to traditional methods.
• Identified specific conditions under which formation of targeted compounds was optimized.
• Revealed insights into the mechanism of the reaction enhancing efficiency.